All 9 games of Round 22, 2021 are complete. The biggest win was Port Adelaide over Carlton by 95 points; the closest was Geelong over St Kilda by 14.
Updated Sat 25 Sep 2021, 10:28pm (Melbourne time)
| Home | Score | Away | Score | Venue |
|---|---|---|---|---|
| Greater Western Sydney | 16.10 (106) | Richmond | 10.7 (67) | Marvel Stadium |
| Hawthorn | 9.10 (64) | Western Bulldogs | 5.7 (37) | York Park |
| Geelong | 13.7 (85) | St Kilda | 11.5 (71) | GMHBA Stadium |
| Port Adelaide | 21.14 (140) | Carlton | 5.15 (45) | Adelaide Oval |
| Brisbane Lions | 22.10 (142) | Collingwood | 8.9 (57) | Gabba |
| North Melbourne | 12.5 (77) | Sydney | 13.13 (91) | Marvel Stadium |
| Melbourne | 16.8 (104) | Adelaide | 9.9 (63) | MCG |
| Gold Coast | 4.6 (30) | Essendon | 14.14 (98) | GMHBA Stadium |
| Fremantle | 12.7 (79) | West Coast | 9.10 (64) | Optus Stadium |