East Melbourne has hosted 225 VFL/AFL games since 1897, including 1 Grand Final.
| Club | P | W | D | L | Win % |
|---|---|---|---|---|---|
| Essendon | 197 | 114 | 4 | 79 | 57.9 |
| University | 34 | 15 | 1 | 18 | 44.1 |
| Geelong | 32 | 8 | 0 | 24 | 25.0 |
| Fitzroy | 31 | 13 | 1 | 17 | 41.9 |
| Carlton | 29 | 14 | 1 | 14 | 48.3 |
| Sydney | 29 | 15 | 0 | 14 | 51.7 |
| Collingwood | 28 | 19 | 1 | 8 | 67.9 |
| Melbourne | 28 | 6 | 1 | 21 | 21.4 |
| St Kilda | 27 | 7 | 1 | 19 | 25.9 |
| Richmond | 15 | 9 | 0 | 6 | 60.0 |
| Year | Round | Home | Score | Away | Result |
|---|---|---|---|---|---|
| 1921 10 Sept | Round 17 | Essendon | 10.14 (74) – 11.8 (74) | Fitzroy | Draw |
| 1921 3 Sept | Round 16 | Essendon | 5.15 (45) – 11.14 (80) | Richmond | Richmond by 35 |
| 1921 23 July | Round 12 | Essendon | 8.13 (61) – 5.13 (43) | Sydney | Essendon by 18 |
| 1921 16 July | Round 11 | Essendon | 2.15 (27) – 9.18 (72) | Geelong | Geelong by 45 |
| 1921 2 July | Round 9 | Essendon | 5.12 (42) – 11.17 (83) | St Kilda | St Kilda by 41 |
| 1921 11 June | Round 6 | Essendon | 7.18 (60) – 18.9 (117) | Carlton | Carlton by 57 |
| 1921 28 May | Round 4 | Essendon | 7.12 (54) – 9.17 (71) | Collingwood | Collingwood by 17 |
| 1921 7 May | Round 1 | Essendon | 11.12 (78) – 12.6 (78) | Melbourne | Draw |
| 1920 4 Sept | Round 18 | Essendon | 6.5 (41) – 15.14 (104) | Richmond | Richmond by 63 |
| 1920 21 Aug | Round 16 | Essendon | 10.7 (67) – 12.11 (83) | Fitzroy | Fitzroy by 16 |
Ground names follow the fixture; games under earlier names count here too (AFL Tables ground record).